28 articles - From Friday Nov 25 2022 to Friday Dec 02 2022
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Nephrol Dial Transplant |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Clin J Am Soc Nephrol |
| J Am Soc Nephrol |
Banff Human Organ Transplant Transcripts Correlate with Renal Allograft Pathology and Outcome: Importance of Capillaritis and Subpathologic Rejection. Peritubular capillary inflammation and DSA are the primary drivers of AMR transcript elevation. Transcripts revealed subpathological evidence of AMR, which often preceded histologic CAMR and subpathological evidence of TCMR that predicted graft loss in CAMR. |
HLA-DQ Mismatches Lead to More Unacceptable Antigens, Greater Sensitization, and Increased Disparities in Repeat Transplant Candidates. HLA-DQ mismatches had the strongest associations with UA-PD, an effect that was greatest in African American and Hispanic recipients. cPRA increases with HLA-DQ UA-PD were equivalent or larger than any other HLA locus. This suggests a need to consider the effects of HLA-DQ in kidney allocation. |
Risk Stratification to Predict Renal Survival in Anti-GBM Disease. Stratifying patients according to the need for RRT at diagnosis and renal histology improves prediction, highlighting the importance of normal glomeruli. Here, we propose a stratification to assist in the management of anti-GBM disease. |
| Kidney Int |
Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis. Thus, molecular profiling identified a subgroup of patients with either MCD or FSGS who shared kidney TNF pathway activation and poor outcomes. A clinical trial testing targeted therapies in patients selected using urinary markers of TNF pathway activation is ongoing. |
Quantitative scoring of progression in transplant glomerulopathy using digital pathology may be superior to Banff cg scoring. Thus, our digital pathology-based approach for scoring TG, accurately assessed progression in TG. However, further validation as a potential surrogate endpoint in clinical trials for the treatment of ABMR is warranted. |
The Pathologic Spectrum of Adenovirus Nephritis in the Kidney Allograft. Thus, we demonstrate that, despite its association with aggressive neutrophil-rich inflammation, ADVN does not often lead to allograft failure. Hence, preventing subsequent acute rejection following resolution of ADVN may improve allograft survival. |
Transitional B cell Cytokines Risk Stratify Early Borderline Rejection After Renal Transplantation. Thus, progressive early allograft inflammation manifest as BL that progresses to late AR in the first post-transplant year represents a high-risk clinical state for poor allograft outcomes. Such high-risk status can be predicted by the T1B IL-10/TNFa ratio before irreversible scarring sets in, thus allowing timely risk stratification. |
| Nephrol Dial Transplant |
Clinical and genetic characteristics of Dent's Disease type 1 in Europe. Results from this large DD1 cohort confirm previous findings and provide new insights regarding age and genotype impact on CKD progression. Our data strongly support that DD1 should be considered in male patients with CKD, nephrocalcinosis/hypercalciuria and non-nephrotic proteinuria and provide additional support for new research opportunities. |
Humoral response after the fourth dose of the SARS-CoV-2 vaccine in the CKD spectrum: a prespecified analysis of the SENCOVAC study. A fourth vaccine dose increased anti-Spike antibody titers or seroconverted many CKD patients, but those with the highest need for a vaccine booster (i.e. those with lower pre-booster antibody titers or KT recipients) derived the least benefit in terms of antibody titers. Admission for breakthrough COVID-19 was associated with low anti-Spike antibody titers. |
RESET-PKD: A pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease. RESET-PKD demonstrates that short-term KDIs potently induce ketogenesis and are feasible for ADPKD patients in daily life. While TLV quickly changed upon the onset of ketogenesis, changes in TKV may require longer-term interventions. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Kidney Dis |
| Nat Rev Nephrol |
Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases. Hyperactivation of mTORC1 leads to podocyte and tubular cell dysfunction and vulnerability to injury, thereby contributing to the development of chronic kidney diseases, including diabetic kidney disease, obesity-related kidney disease and polycystic kidney disease. Emerging evidence suggests that targeting mTOR and/or AMPK could be an effective therapeutic approach to controlling or preventing these diseases. |
| Semin Nephrol |
COVID-19 and the Kidney: Recent Advances and Controversies. Patients at particularly high risk for adverse kidney outcomes include those with APOL1 high-risk genotype status. Biomarkers of injury, inflammation, tubular health, and repair measured in both the blood and urine may hold prognostic significance. |
Does Gender Affirming Hormone Therapy Increase the Risk of Kidney Disease? Improving understanding of the differences in biomarkers and in the development of kidney disease is essential to providing appropriate kidney care to this vulnerable population. In this review, we introduce the current information related to GAHT and kidney health and highlight the significant gaps in our understanding of how GAHT may affect kidney physiology and pathophysiology. |
Where Are They Now: Spatial and Molecular Diversity of Tissue-Resident Macrophages in the Kidney. Multiple studies have identified unique markers that represent these subpopulations, permitting further characterization of the function and roles they play in the kidney. Understanding the diversity of KRM subpopulations will be key in the development of novel therapies used in treating kidney diseases and promoting kidney health. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Clin J Am Soc Nephrol |
| J Am Soc Nephrol |
| Nat Rev Nephrol |
| Nephrol Dial Transplant |
Letters to the editors and authors’ replies